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A Region of Adenylyl Cyclase 2 Critical for Regulation by G Protein βγ Subunits
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A Region of Adenylyl Cyclase 2 Critical for Regulation by G Protein βγ Subunits
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Journal Article
A Region of Adenylyl Cyclase 2 Critical for Regulation by G Protein βγ Subunits
1995
Overview
Receptor-mediated activation of heterotrimeric guanine nucleotide-binding proteins (G proteins) results in the dissociation of α from βγ subunits, thereby allowing both to regulate effectors. Little is known about the regions of effectors required for recognition of Gβγ. A peptide encoding residues 956 to 982 of adenylyl cyclase 2 specifically blocked Gβγ stimulation of adenylyl cyclase 2, phospholipase C-β3, potassium channels, and β-adrenergic receptor kinase as well as inhibition of calmodulin-stimulated adenylyl cyclases, but had no effect on interactions between Gβγ and G$\\alpha_o$. Substitutions in this peptide identified a functionally important motif, Gln-X-X-Glu-Arg, that is also conserved in regions of potassium channels and β-adrenergic receptor kinases that participate in Gβγ interactions. Thus, the region defined by residues 956 to 982 of adenylyl cyclase 2 may contain determinants important for receiving signals from Gβγ.
Publisher
American Society for the Advancement of Science
Subject
