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Expression of tenascin-C and the integrin α9 subunit in regeneration of rat nasal mucosa after chemical injury: involvement in migration and proliferation of epithelial cells
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Expression of tenascin-C and the integrin α9 subunit in regeneration of rat nasal mucosa after chemical injury: involvement in migration and proliferation of epithelial cells
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Expression of tenascin-C and the integrin α9 subunit in regeneration of rat nasal mucosa after chemical injury: involvement in migration and proliferation of epithelial cells
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Journal Article
Expression of tenascin-C and the integrin α9 subunit in regeneration of rat nasal mucosa after chemical injury: involvement in migration and proliferation of epithelial cells
1999
Overview
Nasal mucosa covered by pseudostratified ciliated epithelia can be injured by microbial infection and physical and chemical agents. To elucidate mechanisms of regeneration, erosion of rat nasal mucosa was produced by intranasal instillation of trichloroacetic acid, and tissue specimens were then sequentially obtained after 1–14 days. Since tenascin-C (TN-C) and its receptor, α9β1 integrin, are assumed to play important roles in regeneration of stratified squamous epithelia, their expression was evaluated by immunohistochemistry and in situ hybridization. Three to five days after the injury, TN-C mRNA was found in epithelial cells of migrating fronts and in epithelial sheets recovering ulcerated surfaces between the fronts and normal regions. TN-C deposition was increased under such sheets. Enhanced α9 staining was also evident in the involved epithelium. 5-Bromo-2’-deoxyuridine incorporation assays revealed significant increase in proliferating cells in cell sheets over TN-C deposits at 3–7 days. Therefore, we conclude that regenerating epithelial cells produce and secrete TN-C, associated with an increase in α9 expression, and that interactions between these molecules could regulate migration and proliferation of the epithelial cells in an autocrine manner.
Publisher
Springer Nature B.V
Subject
