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The oncogene makes its escape
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Journal Article
The oncogene makes its escape
2016
Overview
Disruptions in 3D genomic architecture allow cancer genes to evade transcriptional silencing
[Also see Report by
Hnisz
et al.
]
Far from a random tangle, cellular DNA is packed into the nucleus with astounding precision. Indeed, there is growing appreciation for how the three-dimensional (3D) organization of the genome contributes to controlling gene expression. For instance, loops of DNA called insulated neighborhoods can protect small groups of genes from silencing or activation (
1
). If cancer can result from dysregulation of gene expression (
2
), then an enticing hypothesis is that disrupting insulated neighborhoods may lead to increased transcription of cancer genes. On page
1454
of this issue, Hnisz
et al.
(
3
) use tumor-derived sequencing data and targeted deletions in cells to show that disruption of insulated neighborhoods leads to activation of proto-oncogenes—genes with the potential to cause cancer. These findings strongly support disruption of chromatin structure as causally linked to tumorigenesis, and suggest that such disruptions may be the hidden culprit driving many tumors.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
