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Facile fabrication of Gracilaria spinulosa extract-mediated zinc/copper oxide nanocomposite for antimicrobial applications
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Facile fabrication of Gracilaria spinulosa extract-mediated zinc/copper oxide nanocomposite for antimicrobial applications
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Journal Article
Facile fabrication of Gracilaria spinulosa extract-mediated zinc/copper oxide nanocomposite for antimicrobial applications
2026
Overview
Bimetallic nanocomposites represent an important class of nanomaterials with diverse applications in optoelectronics, catalysis, bioimaging, and antimicrobial therapy. In the present study, Gs@Zn/Cu nanocomposites were synthesized via a green synthesis approach. Gracilaria spinulosa seaweed extract was employed to simultaneously load zinc/copper nanoparticles, utilizing its bioactive components as reducing and binding agents. Antibacterial assays demonstrated that the synthesized nanocomposite possesses notable antibacterial activity against Escherichia coli and Staphylococcus aureus . The combination of zinc and copper produced inhibition zones of 20 mm against E. coli and 16 mm against S. aureus . Antibiofilm assays indicated that the Gs@Zn/Cu nanocomposite reduced approximately 85% of biofilm formation at the lowest tested concentrations. Artemia biosafety assays indicated that the synthesized Gs@Zn/Cu nanocomposites are non-toxic and may be suitable for clinical applications. Collectively, these results suggest that bioactive Gs@Zn/Cu nanocomposites have considerable potential as antimicrobial and biomedical materials.
