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Design, Synthesis, Antibacterial and Antifungal Evaluation of 1,2,4-Triazole-thiazolidin-4-one Hybrids
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Design, Synthesis, Antibacterial and Antifungal Evaluation of 1,2,4-Triazole-thiazolidin-4-one Hybrids
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Journal Article
Design, Synthesis, Antibacterial and Antifungal Evaluation of 1,2,4-Triazole-thiazolidin-4-one Hybrids
2023
Overview
A series of previously unknown [5-(substituted phenyl)-4
H
-1,2,4-triazol-4-yl]thiazolidin-4-ones have been successfully synthesized, and their structure has been confirmed by IR and
1
H and
13
C NMR spectroscopy and mass spectrometry. The synthesized compounds have been tested for in vitro activity against bacterial and fungal strains. Compounds containing 4-OCH
3
, 4-NO
2
and 2,3-(OCH
3
)
2
groups in the phenyl ring of the arylidene substituent demonstrated moderate to excellent antibacterial activity, while compounds containing 2-Br, 4-Cl, 4-F, 4-OCH
3
, 4-CH
3
, 2,4-(CH
3
)
2
, and 4-NO
2
groups exhibited excellent to good antifungal activity. The MIC values for the 2,3-(OCH
3
)
2
derivatives against various bacterial strains varied from 12.5 to 50 µg/mL. In terms of the antifungal activity, the 2-Br derivative showed the significant activity against
C. albicans
(MIC 200 µg/mL).
Publisher
Pleiades Publishing,Springer Nature B.V
