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Exploring the mechanistic role of epidermal growth factor receptor activation in non-cancer kidney disease
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Journal Article
Exploring the mechanistic role of epidermal growth factor receptor activation in non-cancer kidney disease
2025
Overview
The epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein that plays a crucial role in signal transduction and cellular responses. This review explores the function of EGFR in kidney physiology and its implications for various kidney diseases. EGFR signaling is essential for kidney function and repair mechanisms, and its dysregulation significantly impacts both acute and chronic kidney conditions. The review discusses the normal distribution of EGFR in kidney tubular segments, the mechanism of its activation and inhibition, and the therapeutic potential of EGFR-targeting antagonists and ligands. Additionally, it explores the pathophysiological characteristics observed in rodent models of kidney diseases through pharmacological and genetic inhibition of EGFR, highlighting therapeutic challenges and limitations such as species differences, variability in disease models, and potential adverse effects. Overall, the findings underscore the multifaceted role of EGFR in kidney diseases, influencing inflammation, fibrosis, and tissue injury. This complex involvement suggests that targeting EGFR may be a beneficial therapeutic strategy for managing these conditions, potentially mitigating inflammation and fibrosis while promoting tissue repair.
Publisher
Tech Science Press
