Journal Article

Cytogenotoxic study of aqueous fruit extract of Morinda citrifolia in Wistar albino rats

Germano Pinho de Moraes, Débora Cássia Vieira Gomes, Muhammad Torequl Islam, Jaqueline Nascimento Picada, Márcia Fernanda Correia Jardim Paz, Marcus Vinícius Oliveira Barros de Alencar, Ana Amélia de Carvalho Melo-Cavalcante, Lidiane da Silva Araújo

2019

Overview

The use of herbal products and/or their derivatives as an alternative or complementary medicine becomes globally popular. To date, various biological activities have been reported in Morinda citrifolia Linn, especially antioxidants, antimicrobial, anti-infammatory and antitumor efects. This study aimed to investigate the genotoxicity and DNA repair capacity of the aqueous fruit extract of M. citrifolia (AEMC). Additionally, we checked the mutagenic capacity of AEMC by the comet assay and micronucleus tests in rats. For this, rats (n=10; 5 males and 5 females) were divided into fve groups as: negative control (distilled water); positive control (25 mg/kg of cyclophosphamide, i.p.); and three groups for AEMC (2.5, 5 and 10 mg/kg, i.p.). The results suggest that, the AEMC induced genotoxicity in white blood cells, but a DNA repair capacity was also observed after 72 h of AEMC exposure. AEMC also showed cytotoxicity and mutagenicity in liver and kidney cells of rats at 5 and 10 mg/kg doses. In conclusion, AEMC exhibited a dose-dependent cytotoxicity, genotoxicity and mutagenicity along with a time-dependent DNA repair capacity in rats. Further studies are necessary regarding the safe use of this medicinal plant for human consumption. KCI Citation Count: 0

• Publisher: 융합한의과학연구소
• Subject: 한의학