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Correction: VZV IE4 downregulates cellular surface MHC-I via sequestering it to the golgi complex
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Correction: VZV IE4 downregulates cellular surface MHC-I via sequestering it to the golgi complex
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Journal Article
Correction: VZV IE4 downregulates cellular surface MHC-I via sequestering it to the golgi complex
2025
Overview
The paragraph “mIE4 VZV fails to downregulate MHC-I on the cell surface To characterize the function of IE4 during VZV infection, a mIE4 VZV was constructed as described in our previous study (Fig. 4A) [30] and showed a similar growth curve with WT VZV (data not shown). [...]flow cytometry analysis revealed that WT or ORF66-flag VZV significantly downregulated cellular surface MHC-I, whereas mIE4 VZV had a weaker effect (Fig. 4B). Confocal microscopy analysis revealed that WT VZV infection resulted in the retention of HLA-C-Red in the Golgi complex, similar to the ectopic expression of IE4 (Fig. 3A). [...]flow cytometry analysis revealed that WT or ORF66-flag VZV significantly downregulated cellular surface MHC-I, whereas mIE4 VZV had less effect (Fig. 4C). Confocal microscopy analysis revealed that WT VZV infection resulted in the retention of HLA-C-Red in the Golgi complex, similar to the ectopic expression of IE4 (Fig. 3A). The sentence Nonetheless, PAA was used to inhibit viral DNA replication in their study, suggesting that VZV IE or early gene product(s) is involved in the regulation of cellular surface MHC-I, and ORF66 delay the MHC-I transport from the ER to the cis/ medial-Golgi [20]. [...]they also demonstrated that VZV lacking ORF66 expression maintains the ability to downregulate cellular surface MHC-I [20], implying that one or more ORF66-independent genes might affect cellular surface MHC-I. in this article should have read as Nonetheless, PAA was used to inhibit viral DNA replication in their study, suggesting that VZV IE or early gene product(s) are involved in the regulation of cellular surface MHC-I, and ORF66 delay the MHC-I transport from the ER to the cis/medial-Golgi [20].
Publisher
Springer International Publishing,Springer Nature B.V,Springer
Subject
