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Novel strategies in treatment of acute promyelocytic leukemia
by
Lo-Coco, F
, Cicconi, L
in
Antineoplastic agents
/ Biological and medical sciences
/ Cancer Research
/ Chemotherapy
/ Critical Care Medicine
/ Hematologic and hematopoietic diseases
/ Hematology
/ Intensive
/ Internal Medicine
/ Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
/ Medical sciences
/ Medicine & Public Health
/ Oncology
/ Pharmacology. Drug treatments
/ Proceedings
/ proceedings-article
2012
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Novel strategies in treatment of acute promyelocytic leukemia
by
Lo-Coco, F
, Cicconi, L
in
Antineoplastic agents
/ Biological and medical sciences
/ Cancer Research
/ Chemotherapy
/ Critical Care Medicine
/ Hematologic and hematopoietic diseases
/ Hematology
/ Intensive
/ Internal Medicine
/ Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
/ Medical sciences
/ Medicine & Public Health
/ Oncology
/ Pharmacology. Drug treatments
/ Proceedings
/ proceedings-article
2012
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While trying to remove the title from your shelf something went wrong :( Kindly try again later!
Do you wish to request the book?
Novel strategies in treatment of acute promyelocytic leukemia
by
Lo-Coco, F
, Cicconi, L
in
Antineoplastic agents
/ Biological and medical sciences
/ Cancer Research
/ Chemotherapy
/ Critical Care Medicine
/ Hematologic and hematopoietic diseases
/ Hematology
/ Intensive
/ Internal Medicine
/ Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
/ Medical sciences
/ Medicine & Public Health
/ Oncology
/ Pharmacology. Drug treatments
/ Proceedings
/ proceedings-article
2012
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Novel strategies in treatment of acute promyelocytic leukemia
Journal Article
Novel strategies in treatment of acute promyelocytic leukemia
2012
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Overview
Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia characterized by t(15;17) and a life-threatening coagulopathy. Once highly fatal, nowadays standard treatment approaches with all-trans retinoic acid (ATRA) along with chemotherapy allows curing up to 80–85% of cases. In the past decade, arsenic trioxide used alone or in combination with ATRA has demonstrated high efficacy in APL, and is currently regarded as the gold standard for treatment of relapsed cases. Chemotherapy-free approaches based on the combination of arsenic trioxide and ATRA are currently being tested against standard ATRA and chemotherapy in randomized clinical trials for frontline therapy of APL.
Publisher
Nature Publishing Group UK,Nature Publishing Group
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