Journal Article

Characteristics and antimicrobial susceptibility of bacteria causing acute otitis media in children at Vietnam National Children’s Hospital: a cross-sectional study

Guzman-Holst, Adriana, DeAngelis, Elena, Đỗ, Hồng Điệp, Thân, Hữu Tiệp, Liên Phạm, Thị Lan, Thủy Phùng, Thị Bích, Nguyễn, Tuyết Xương, Trần, Minh Điển, Ngọc Hoàng, Thị Bích, Nguyen, Minh, Nguyễn, Khắc Trưởng

2025

Overview

Acute otitis media (AOM) is a leading cause of healthcare visits, antibiotic prescription and complications in children aged under 5 years. Following the introduction of pneumococcal conjugate vaccines (PCVs), non-typeable (NTHi) has become the most common causative agent for AOM, followed by and . PCVs are not yet included in the National Immunization Program in Vietnam. To determine the frequency and characteristics of the pathogens related to AOM in Vietnam in children ≤5 years old. This was a cross-sectional study performed at the Vietnam National Children's Hospital from October 2021 to December 2023 in children ≤5 years old diagnosed with acute suppurative otitis media. Clinical features of the children were described. Pathogens of interest were identified by culture or real-time PCR (rtPCR). The antibiotic susceptibility profiles of and isolates were determined. In total, 482 children ≤5 years old were included, of which 70.8% were ≤2 years old and 61% had an history of AOM. The most frequent bacteria isolated were (52.1%, 99.6% of which were NTHi) and (41.1%). Most isolates were resistant to azithromycin, clarithromycin and cefuroxime. Most isolates were resistant to amoxicillin, cefixime, cefuroxime, azithromycin and clarithromycin. The pathogens most frequently associated with AOM in this study were in line with previous findings. Many isolates were resistant to commonly given oral antibiotics. These results can inform decision-making on AOM prevention and treatment strategies in Vietnam.