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Impact of niacin combined with ubiquinone on inhibition of lipoprotein lipase as a mechanism of anti-obesity and antiatherogenic agents in rats fed on high-fat diet
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Impact of niacin combined with ubiquinone on inhibition of lipoprotein lipase as a mechanism of anti-obesity and antiatherogenic agents in rats fed on high-fat diet
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Impact of niacin combined with ubiquinone on inhibition of lipoprotein lipase as a mechanism of anti-obesity and antiatherogenic agents in rats fed on high-fat diet
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Journal Article
Impact of niacin combined with ubiquinone on inhibition of lipoprotein lipase as a mechanism of anti-obesity and antiatherogenic agents in rats fed on high-fat diet
2025
Overview
Niacin is one of the B-complex vitamins that play an important role in metabolic pathways, while ubiquinone (Coenz-Q) is a component of the electron transport chain required for energy production. This study evaluated the role of niacin combined with ubiquinone in the inhibition of lipoprotein lipase as a mechanism of anti-obesity and antiatherogenic agents in rats fed on a High-Fat Diet (HFD). To achieve this purpose, sixty male albino rats (100– 150 g) were used in this study and divided into six groups (10 each). Group I (control): rats fed on a normal diet. Group II: Rats fed on HFD. Group III: Rats fed HFD and were given Niacin at 10 mg/kg body weight (b.w)/day orally by stomach tube. Group IV: Rats fed HFD and were given Coenz-Q (10 mg /kg b.w/day) orally. Group V: Rats fed HFD were given Niacin (10 mg/kg b.w/day) and Coenz- Q (10 mg /kg b.w/day). Group VI: Rats were given a hypocholesterolemic agent (cholerose) orally (10 mg/kg b.w/day) as positive control. The obtained results showed that treatment with Niacin or Coenz-Q or combined increased the activity of lipoprotein lipase (p < 0.001) and reduced the atherogenic effect and obesity index (p<0.001). The combined treatment is more effective than individual one or cholerose. In conclusion, Niacin combined with Coenz- Q increased lipid clearance and prevented its accumulation in blood. This combination is promising as antiatherogenic agent. Further investigation is required to identify the pathways regulated by these supplements that help in weight management.
Publisher
PAGEPress Publications
Subject
