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Exploring Antibacterial Properties of Mechanochemically Synthesized MgAl2O4 Spinel Nanoparticles for Dental and Medical Applications
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Journal Article
Exploring Antibacterial Properties of Mechanochemically Synthesized MgAl2O4 Spinel Nanoparticles for Dental and Medical Applications
2025
Overview
Magnesium aluminate spinel nanoparticles (MgAl2O4-S-NPs) represent a promising class of nanoceramics with potential biomedical applications due to their physicochemical stability and antimicrobial properties. This study aimed to determine the structural characteristics, composition, and biological performance of MgAl2O4 spinel nanoparticles that were synthesized via a mechanochemical method. Structural and compositional characterization was performed using X-ray diffraction (XRD) and high-resolution transmission electron microscopy (HR-TEM). Antibacterial activity was evaluated against Helicobacter pylori and Enterococcus faecalis using bacterial viability assays. Structural and morphological analyses confirmed the successful formation of single-phase cubic MgAl2O4 with a polyhedral morphology and nanoscale size distribution. Bacterial viability was quantified through optical density measurements following exposure to MgAl2O4-S-NPs at different concentrations. The nanoparticles exhibited both bacteriostatic and bactericidal effects, with activity being demonstrated against the tested bacterial strains. Mechanochemically synthesized MgAl2O4-S-NPs are promising candidates for biomedical applications, including dental materials, antimicrobial coatings, and infection-control strategies. Overall, the findings highlight the potential of MgAl2O4-S-NPs as effective antimicrobial agents that can be produced through an environmentally friendly synthesis route.
Publisher
MDPI AG
Subject
