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Effect of ABCB1 Inhibition at the Blood-Brain Barrier On Brain Distribution of the ABCB1 Substrate (R)-11C Verapamil in Elderly Versus Young Subjects
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Effect of ABCB1 Inhibition at the Blood-Brain Barrier On Brain Distribution of the ABCB1 Substrate (R)-11C Verapamil in Elderly Versus Young Subjects
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Effect of ABCB1 Inhibition at the Blood-Brain Barrier On Brain Distribution of the ABCB1 Substrate (R)-11C Verapamil in Elderly Versus Young Subjects
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Journal Article
Effect of ABCB1 Inhibition at the Blood-Brain Barrier On Brain Distribution of the ABCB1 Substrate (R)-11C Verapamil in Elderly Versus Young Subjects
2017
Overview
There were no significant differences in the area under the curve of unmetabolized (R)-[11C]verapamil in plasma between the elderly and young group, both for baseline scans and scans after ABCB1 inhibition. [...]tariquidar plasma concentrations at the time of the PET scan were not significantly different between the two groups.
Publisher
Elsevier Inc,Elsevier Limited
