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Saccharin, sorbic acid, and erythrosine-B induce DNA methyltransferase expression and modulate apoptotic genes in MCF-7 and U87-MG cells
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Saccharin, sorbic acid, and erythrosine-B induce DNA methyltransferase expression and modulate apoptotic genes in MCF-7 and U87-MG cells
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Saccharin, sorbic acid, and erythrosine-B induce DNA methyltransferase expression and modulate apoptotic genes in MCF-7 and U87-MG cells
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Journal Article
Saccharin, sorbic acid, and erythrosine-B induce DNA methyltransferase expression and modulate apoptotic genes in MCF-7 and U87-MG cells
2026
Overview
Abstract
This study aimed to investigate the cytotoxic effects of erythrosine-B (ErB), saccharin, and sorbic acid (SA) on human breast adenocarcinoma (MCF-7) and glioblastoma (U87-MG) cell lines and the expression levels of DNA methyltransferases (DNMT1, DNMT3a) and genes involved in the apoptotic process (Bax, Bcl-2). After treatment, RT-QPCR was used to analyse the gene expression levels. In addition, the suppressive effects of different doses of these additives on cell proliferation on MCF-7 and U87 MG cells were determined by the MTT method. Our findings show that saccharin, SA, and ErB significantly up-regulated DNMT1 and DNMT3a gene expression compared to the control group. A dose-dependent increase in Bax and Bcl-2 gene expression was observed. This, when considered together with the cytotoxic/genotoxic effects observed in the study, suggests that the substance may simultaneously trigger both pro- and anti-apoptotic signals. This dual regulation reflects the complexity of the cellular response. These results suggest that saccharin, SA, and ErB may have an effect on both epigenetic regulations and apoptotic mechanisms.
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Publisher
Oxford University Press
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