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New coumestans: synthesis, cytotoxic and antioxidant activity
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Journal Article
New coumestans: synthesis, cytotoxic and antioxidant activity
2024
Overview
New 4-hydroxycoumarins and coumestans with
tert
-butyl and isobornyl substituents were synthesized. The cytotoxic profile and the antioxidant status of the synthesized compounds were assessed using
in vitro
models. The promise of the coumestans studied as potential antitumor agents is demonstrated. A possible mechanism of the action of the title compounds is associated with the antioxidant activity expressed in the ability to inhibit the process of lipid peroxidation and with the direct antiradical activity in the ORAC and DPPH assays.
Publisher
Springer US,Springer Nature B.V
