Asset Details
Do you wish to reserve the book?
Enantioselective synthesis of tetrasubstituted allenes via addition/arylation tandem reaction of 2-activated 1,3-enynes
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Enantioselective synthesis of tetrasubstituted allenes via addition/arylation tandem reaction of 2-activated 1,3-enynes
Do you wish to request the book?
Enantioselective synthesis of tetrasubstituted allenes via addition/arylation tandem reaction of 2-activated 1,3-enynes
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Enantioselective synthesis of tetrasubstituted allenes via addition/arylation tandem reaction of 2-activated 1,3-enynes
2023
Overview
We report the development of a new class of multifunctional chiral guanidine/Pd(0) catalyst system for 1,4-addition/arylation tandem reaction. A variety of tetra-substituted allenes were readily accessible from three-component “one-pot” transformations of acyclic or cyclic 2-activated 1,3-enynes, malonates and halobenzenes under mild reaction conditions. High levels of yield and enantioselectivity were achieved in the construction of stereogenic center and axis using readily available acyclic guanidine-amides. The mechanistic studies suggest that the guanidine/Pd(0) collaboration has obvious synergism to both base-dominated conjugate addition, and Pd(0)-dominated Heck-type reaction.
Publisher
Science China Press,Springer Nature B.V
