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Antibacterial activity of ruthenium polypyridyl complexes against Staphylococcus aureus and biofilms
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Journal Article
Antibacterial activity of ruthenium polypyridyl complexes against Staphylococcus aureus and biofilms
2020
Overview
There is clearly a need for the development of new classes of antimicrobials to fight against multidrug-resistant bacteria. Here, we designed and synthesized of three ruthenium polypyridyl complexes: [Ru(bpy)
2
(BTPIP)](ClO
4
)
2
(
Ru(II)-1
), [Ru(bpy)
2
(ETPIP)](ClO
4
)
2
(
Ru(II)-2
) and [Ru(bpy)
2
(CAPIP)](ClO
4
)
2
(
Ru(II)-3
) (
N
-
N
= bpy = 2,2′-bipyridine), their antimicrobial activities against
S. aureus
were assessed. The lead complexes of this set,
Ru(II)-1
(MIC = 0.016 mg/mL), was tested against biofilm. We also investigated whether bacteria can easily develop resistance to
Ru(II)-1
. The result demonstrated that
S. aureus
could not easily develop resistance to the ruthenium complexes. In addition, aimed to test whether ruthenium complexes treatment could increase the susceptibility of
S. aureus
to antibiotics, the synergism between
Ru(II)-1
and common antibiotics against
S. aureus
were investigated using the checkerboard method. Interesting,
Ru(II)-1
could increased the susceptibility of
S. aureus
to some aminoglycoside antibiotics(kanamycin and gentamicin). Finally, in vivo bacterial infection treatment studies were also conducted through murine skin infection model. These results confirmed ruthenium complexes have good antimicrobial activity in vitro and in vivo.
Graphic abstract
Publisher
Springer Berlin Heidelberg,Springer Nature B.V
Subject
/ Anti-Bacterial Agents - chemical synthesis
/ Anti-Bacterial Agents - chemistry
/ Anti-Bacterial Agents - pharmacology
/ Antiinfectives and antibacterials
/ Bacteria
/ Biofilms
/ Biomedical and Life Sciences
/ Coordination Complexes - chemical synthesis
/ Coordination Complexes - chemistry
/ Coordination Complexes - pharmacology
/ Ligands
/ Minimum inhibitory concentration
