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Stimuli‐Responsive Aggregation‐Induced Emission Materials for Tumor Theranostics: Design Strategies and Biomedical Applications
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Stimuli‐Responsive Aggregation‐Induced Emission Materials for Tumor Theranostics: Design Strategies and Biomedical Applications
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Journal Article
Stimuli‐Responsive Aggregation‐Induced Emission Materials for Tumor Theranostics: Design Strategies and Biomedical Applications
2026
Overview
Smart‐responsive aggregation‐induced emission (AIE) materials have emerged as promising bio‐nanomaterials for tumor diagnosis and therapy due to their enhanced fluorescence in aggregated states, overcoming the aggregation‐caused quenching of traditional fluorophores. These materials enable the construction of efficient imaging and therapeutic platforms in complex biological environments. Stimuli‐responsive AIE systems can be categorized into pH‐, redox‐, thermo‐, enzyme‐responsive, and externally triggered types. Despite significant progress in AIE‐based tumor imaging and therapy, critical challenges in their rational design and biomedical application remain insufficiently addressed. This review summarizes recent advances in stimuli‐responsive AIE materials for tumor theranostics, focusing on their design strategies, functional mechanisms, and representative applications. Current limitations and future perspectives are also discussed to guide the development of next‐generation AIE‐based platforms.
Publisher
Wiley,Wiley-VCH
