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How Much Daily Image-guided Volumetric Modulated Arc Therapy Is Useful for Proctitis Prevention With Respect to Static Intensity Modulated Radiotherapy Supported by Topical Medications Among Localized Prostate Cancer Patients?
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How Much Daily Image-guided Volumetric Modulated Arc Therapy Is Useful for Proctitis Prevention With Respect to Static Intensity Modulated Radiotherapy Supported by Topical Medications Among Localized Prostate Cancer Patients?
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Journal Article
How Much Daily Image-guided Volumetric Modulated Arc Therapy Is Useful for Proctitis Prevention With Respect to Static Intensity Modulated Radiotherapy Supported by Topical Medications Among Localized Prostate Cancer Patients?
2021
Overview
To evaluate if topical support therapy during static-intensity modulated radiotherapy (sIMRT) course is able to equal the characteristic minimum risk for radiation proctitis of Image-guided volumetric modulated arc therapy (IG-VMAT) treatment among localized prostate cancer patients.
Rectal toxicity data of the above patients were retrospectively collected throughout three different clinical periods at our Radiotherapy Deparment: from October 2011 to December 2012, prostate cancer patients were treated with sIMRT and in advance supported by means of daily topical corticosteroids; from January 2013 to November 2016, topical corticosteroids were replaced by daily hyaluronic acid enemas; from December 2016 to May 2018 eligible patients were treated with newly introduced IG-VMAT supported by only on-demand topical corticosteroids.
Among 359 eligible patients, IG-VMAT was proven generally more effective than sIMRT supported by topical medications in terms of proctitis reduction, although without clinical and practical relevance.
Topical medications might have a role in radiation proctitis prevention.
Publisher
International Institute of Anticancer Research
Subject
/ Aged
/ Anti-Inflammatory Agents - administration & dosage
/ Beclomethasone - administration & dosage
/ Humans
/ Hyaluronic Acid - administration & dosage
/ Italy
/ Male
/ Organ Sparing Treatments - methods
/ Patients
/ Proctitis - prevention & control
/ Prostatic Neoplasms - drug therapy
/ Prostatic Neoplasms - pathology
/ Prostatic Neoplasms - radiotherapy
/ Radiation Dose Hypofractionation
/ Radiation Injuries - prevention & control
/ Radiotherapy Planning, Computer-Assisted - methods
/ Radiotherapy, Image-Guided - adverse effects
/ Radiotherapy, Image-Guided - methods
/ Radiotherapy, Intensity-Modulated - adverse effects
/ Radiotherapy, Intensity-Modulated - methods
/ Rectum
/ Steroids
/ Toxicity
