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Malignant Peripheral Nerve Sheath Tumor With Rhabdomyosarcomatous Differentiation (Malignant Triton Tumor)
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Malignant Peripheral Nerve Sheath Tumor With Rhabdomyosarcomatous Differentiation (Malignant Triton Tumor)
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Journal Article
Malignant Peripheral Nerve Sheath Tumor With Rhabdomyosarcomatous Differentiation (Malignant Triton Tumor)
2006
Overview
Malignant peripheral nerve sheath tumors arise from Schwann cells or within existing neurofibromas and have a strong association with type 1 neurofibromatosis. These tumors are histologically diverse and may contain malignant areas of divergent mesenchymal differentiation, the most common of which is skeletal muscle (rhabdomyosarcoma). Malignant peripheral nerve sheath tumor with rhabdomyosarcomatous differentiation is also known as malignant triton tumor. Malignant triton tumor has a worse prognosis than classic malignant peripheral nerve sheath tumor does, and the correct diagnosis requires attention to the clinical history and knowledge of the complexities regarding its differential diagnosis. In this review we discuss the clinical, histopathological, immunohistochemical, and prognostic features of this rare neoplasm.
Publisher
College of American Pathologists
Subject
/ Biomarkers, Tumor - analysis
/ Humans
/ Melanoma
/ Myelin Basic Protein - analysis
/ Nerve Sheath Neoplasms - chemistry
/ Nerve Sheath Neoplasms - pathology
/ Nerve Sheath Neoplasms - surgery
/ Rhabdomyosarcoma - chemistry
/ Rhabdomyosarcoma - pathology
/ Sarcoma
/ Soft Tissue Neoplasms - chemistry
/ Soft Tissue Neoplasms - pathology
/ Soft Tissue Neoplasms - surgery
/ Tumors
