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Pharmacogenetics of methotrexate response in rheumatoid arthritis: an update
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Pharmacogenetics of methotrexate response in rheumatoid arthritis: an update
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Pharmacogenetics of methotrexate response in rheumatoid arthritis: an update
Pharmacogenetics of methotrexate response in rheumatoid arthritis: an update
Journal Article

Pharmacogenetics of methotrexate response in rheumatoid arthritis: an update

2020
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Overview
[...]it is vital that baseline characteristics predictive of response to MTX are discovered to prevent long-term disability. The DAS28 is a weighted score of the number of tender and swollen joints out of 28, the patient’s global assessment of arthritis activity on a visual analog scale (VAS, 0-100mm) and a biochemical maker of inflammation (erythrocyte sedimentation rate, ESR or C-reactive protein, CRP). [...]predicting MTX response and developing stratified medicine techniques is vital. [...]there is variation in treatment outcome measures between studies and most utilize the DAS28, which includes subjective patient-reported outcome measures (TJC, VAS), as previously discussed.