Asset Details
Do you wish to reserve the book?
Synthesis and in vitro cytotoxicity evaluation of some N-substituted α-amino acid derivatives containing a hexahydropyrimidine moiety
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Synthesis and in vitro cytotoxicity evaluation of some N-substituted α-amino acid derivatives containing a hexahydropyrimidine moiety
Do you wish to request the book?
Synthesis and in vitro cytotoxicity evaluation of some N-substituted α-amino acid derivatives containing a hexahydropyrimidine moiety
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Synthesis and in vitro cytotoxicity evaluation of some N-substituted α-amino acid derivatives containing a hexahydropyrimidine moiety
2017
Overview
This work reports a one-pot synthesis of diastereomerically pure
N
-substituted derivatives of natural amino acids containing a hexahydropyrimidine moiety in 71–89% yields by Mannich reaction of ethyl acetoacetate or 3-oxobutanamide with formaldehyde and amino acid hydrochlorides in acetate buffer (AcONa–AcOH, pH 4) at room temperature. The in vitro cytotoxic activities of the compounds obtained were determined in cancer (Jurkat and SH-SY5Y) and conditionally normal (HEK293) human cells.
Publisher
Springer US,Springer Nature B.V
