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Extended-Spectrum β-Lactamase–Producing Enterobacteriaceae in Children: Old Foe, Emerging Threat
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Extended-Spectrum β-Lactamase–Producing Enterobacteriaceae in Children: Old Foe, Emerging Threat
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Journal Article
Extended-Spectrum β-Lactamase–Producing Enterobacteriaceae in Children: Old Foe, Emerging Threat
2015
Overview
Extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae present an ever-growing burden in the hospital and community settings, across all ages and demographics. Infections due to ESBL-containing pathogens continue to be associated with significant morbidity and mortality worldwide. With widespread empiric broad-spectrum β-lactam use creating selective pressure, and the resultant emergence of stable, rapidly proliferating ESBL-producing clones with continued horizontal gene transfer across genera, addressing this issue remains imperative. Although well characterized in adults, the epidemiology, risk factors, outcomes, therapies, and control measures for ESBL-producing bacteria are less appreciated in children. This analysis provides a brief summary of ESBL-producing Enterobacteriaceae in children, with a focus on recent clinical and molecular data regarding colonization and infection in nonoutbreak settings.
Publisher
Oxford University Press
Subject
/ Anti-Bacterial Agents - therapeutic use
/ beta-Lactamases - biosynthesis
/ Child
/ Drug Resistance, Multiple, Bacterial
/ Enterobacteriaceae - drug effects
/ Enterobacteriaceae - enzymology
/ Enterobacteriaceae - genetics
/ Enterobacteriaceae - pathogenicity
/ Enterobacteriaceae Infections - drug therapy
/ Enterobacteriaceae Infections - epidemiology
/ Enterobacteriaceae Infections - microbiology
/ Humans
/ Invited
