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Modeling
by
Miller, Neil A.
in
Administration, Inhalation
/ Invited Review Article
/ Lung
/ Models, Biological
2024
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Modeling
by
Miller, Neil A.
in
Administration, Inhalation
/ Invited Review Article
/ Lung
/ Models, Biological
2024
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Journal Article
Modeling
2024
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Overview
Modeling is coming to the fore as it is now widely accepted and indeed expected during drug discovery and development. Modeling integrates knowledge, increases understanding and provides the ability to predict an outcome either before it occurs or when it is not possible to measure. This makes modeling an attractive option for inhaled drugs as it is not possible to routinely measure what is occurring to the drug (pharmacokinetics) and what effect the drug is having (pharmacodynamics) at local microscopic sites of such a diverse and complex organ as the lung. Many pieces of information (data and knowledge) exist like the pieces of a jigsaw puzzle and modeling brings the pieces together in a scientific and mechanistically coherent manner to increase understanding of both the efficacy and safety of inhaled drugs.
Publisher
Mary Ann Liebert, Inc., publishers,SAGE Publications
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