Asset Details
Do you wish to reserve the book?
Telomeric RNAs, TERRA, as a Potential Biomarker for Spermatozoa Quality
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Telomeric RNAs, TERRA, as a Potential Biomarker for Spermatozoa Quality
Do you wish to request the book?
Telomeric RNAs, TERRA, as a Potential Biomarker for Spermatozoa Quality
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Telomeric RNAs, TERRA, as a Potential Biomarker for Spermatozoa Quality
2024
Overview
Characterization of long non-coding telomeric repeat-containing RNAs in sperm of normozoospermic and oligoasthenozoospermic men as new biomarker of idiopathic male infertility. We conducted an observational prospective study with two groups of men with normal or orligoasthenozoospermic spermiogram, aged 40 and above. Fertility parameters were analyzed in men undergoing intracytoplasmic sperm injection with donor oocytes, to avoid the female factor. Telomeric RNAs and telomere length were measured by quantitative fluorescent in situ hybridization. Data from seminal parameters and in-vitro fertilization were assessed according to IVIRMA protocols. Patients with oligoasthenozoospermia, who had worse seminal parameters, also obtained embryos with lower inner-cell-mass quality (
p
= 0.04), despite using donor oocytes. While mean levels of telomeric RNAs were similar for both groups, the percentage of spermatozoa with more than 3 foci was higher in oligoasthenozoospermic men (
p
= 0.02). Regarding telomere length, oligoasthenozoospermic men had shorter mean, a higher accumulation of short telomeres (15th percentile;
p
= 0.03) and a lower percentage of very-long telomeres (85th percentile;
p
= 0.01). Finally, a positive correlation was found between telomeric-RNAs intensity and total progressive motility in the spermatozoa of normozoospermic patients (r = 0.5;
p
= 0.03). Telomeric parameters were altered in the spermatozoa of the oligoasthenozoospermic group, which also showed lower quality embryos. Interestingly, in the normozoospermic group, a correlation was found between progressive motility and telomeric RNA levels, suggesting that they could be a good biomarker of sperm quality. Further studies are required to confirm these results and translate them into the clinical practice.
Trial registration number: 1711-MAD-109-CB, 07/07/2021.
Publisher
Springer International Publishing
Subject
/ Asthenozoospermia - diagnosis
/ Asthenozoospermia - genetics
/ Asthenozoospermia - metabolism
/ Humans
/ Infertility, Male - diagnosis
/ Infertility, Male - genetics
/ Infertility, Male - metabolism
/ Male
/ Medicine
/ Obstetrics/Perinatology/Midwifery
/ Reproductive Biology: Original Article
/ RNA, Long Noncoding - genetics
/ RNA, Long Noncoding - metabolism
