Journal Article

Outcomes of kidney transplantation in HIV-positive patients: the UK experience

Marshall, Neal, Boffito, Marta, Jones, Rachael, Post, Frank A, Levy, Jeremy B, Khoo, Saye H, Gathogo, Esther, Hilton, Rachel, Harber, Mark, Hamzah, Lisa, Drage, Martin, Bhagani, Sanjay

2013

Overview

HIV infection is an independent risk factor for end-stage kidney disease in HIV-positive patients of black ethnicity. Highly effective antiretroviral therapy has allowed these patients to be considered for kidney transplantation (KT). We report the outcomes of KT in a national observational cohort study. We retrospectively identified HIV-positive patients who had undergone KT up to December, 2010, through all 25 UK KT centres and major HIV clinics, and included follow-up until December, 2011. Patient characteristics, treatments, and complications were described. Patient and graft survival rates and cumulative incidence of acute rejection were estimated with Kaplan-Meier and Nelson-Aalen analyses. 35 HIV-positive KT recipients (median age 40 years, 66% male, 74% black ethnicity) were identified. At the time of KT, all patients were stable on antiretroviral therapy with undetectable HIV RNA and median CD4 cell count of 366 cells per mL. Patient survival at both 1 and 3 years was 91·3%, and graft survival was 91·3% and 84·7%, respectively. In the first year after KT, blood concentrations of calcineurin inhibitors (CNI) were frequently outside the therapeutic reference range. At 1 year after KT, the cumulative incidence of acute allograft rejection was 48%, and the median estimated glomerular filtration rate 61 mL/min/1·73 m2 (IQR 46–78). Although HIV viraemia and HIV disease progression were uncommon, renal complications were relatively frequent. Our study corroborates the feasibility of KT in HIV-positive patients. Co-administration of antiretroviral therapy and CNI is challenging, and sub-therapeutic CNI concentrations may contribute to the high rate of acute allograft rejection. The optimum immune suppression strategy in this population remains to be refined. King's College London.

• Publisher: Elsevier Ltd,Elsevier Limited
• Subject: Antiretroviral agents / blood / cohort studies / disease course / glomerular filtration rate / graft rejection / HIV infections / Internal Medicine / kidney diseases / kidney transplant / Kidney transplantation / nationalities and ethnic groups / Observational studies / patients / Risk factors / RNA / Survival / survival rate / United Kingdom / viremia