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Relation of microvascular dysfunction to exercise capacity and symptoms in patients with severe aortic stenosis
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Relation of microvascular dysfunction to exercise capacity and symptoms in patients with severe aortic stenosis
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Journal Article
Relation of microvascular dysfunction to exercise capacity and symptoms in patients with severe aortic stenosis
2011
Overview
Exclusion criteria: syncope; other moderate/severe valve disease, previous valve surgery, obstructive coronary artery disease (>50% luminal stenosis on invasive angiography), chronic obstructive pulmonary disease, atrial fibrillation, estimated glomerular filtration rate <30mL/min. Investigations and primary outcome measures; cardiac magnetic resonance (CMR) - left ventricular mass index (LVMI), MPR (calculated from absolute myocardial blood flow during adenosine hyperaemia and rest determined by model-independent deconvolution of signal intensity curves with an arterial input function), late gadolinium enhancement (LGE); echocardiography - AS severity, tissue Doppler-derived diastolic function; symptom-limited bicycle ergometer cardiopulmonary exercise testing (CPEX) - peak VO2.
Publisher
BioMed Central,Elsevier
Subject
