Journal Article

Distinguishing Tics Secondary To Juvenile Huntington’s Disease From A Primary Tic Disorder

Sarna, Justyna R., Chan, Jason L.

2024

Overview

[...]tics in these cases could be due to a concurrent primary tic disorder instead of secondary to JHD. Fine motor control impairment, irritability, tonic–clonic seizures, gait ataxia, and dystonia Chorea and cognitive impairment in father and 6 paternal family members across 3 generations 108 in patient; 47 in father; 52 in paternal uncle; 50 in paternal aunt Liu et al. 20146 10 years M Motor tics (limbs) Motor (limbs), no further details Gait disturbance, dysarthria, involuntary head wiggle, and foot dystonia None 82 in patient; no genetic testing for family Cui et al. 20177 9 years M Simple motor tics (blinking), complex motor tics (frowning), and simple phonic tics (throat clearing) Simple motor (blinking, jerking of head, shoulders, right upper limb, and lower limbs), complex motor (frowning), and simple phonic (throat clearing). Torticollis, ADHD, OCD, and night terrors None 49 in patient; <20 in mother and father Lesinskiene et al. 20208 11 years M Simple phonic tics (coughing and throat clearing) Simple phonic (coughing and throat clearing) Involuntary head and neck movements, irritable, social withdrawal, cognitive impairment, rigidity, dysarthria, depression, and psychosis HD in father and paternal family members across several generations 52 in patient; genetic testing not reported for family Lesinskiene et al. 20208 13 years M Simple phonic tics (throat clearning), involuntary chest and hip twitching during sleep, unsteady gait, rigidity, and dysarthria Simple phonic (throat clearing) Social withdrawal, cognitive impairment, hyperkinetic movements, impulsivity, and dysphagia HD in father and 1 paternal family member 69 in patient In contrast, our case had characteristics that support tics occurring secondary to JHD rather than a concurrent primary tic disorder.

• Publisher: Cambridge University Press
• Subject: Age / Ataxia / Attention deficit hyperactivity disorder / Caregivers / Cognitive ability / Dysarthria / Dysphagia / Dystonia / Etiology / Family medical history / Gait / Genetic testing / Humans / Huntington Disease - complications / Huntington Disease - diagnosis / Huntingtons disease / Letter to the Editor: New Observation / Movement disorders / Neurodegeneration / Obsessive compulsive disorder / Tic Disorders - diagnosis / Tic Disorders - etiology / Tics - diagnosis / Tics - etiology