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In angioimmunoblastic T-cell lymphoma, neoplastic T cells may be a minor cell population. A molecular single-cell and immunohistochemical study
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In angioimmunoblastic T-cell lymphoma, neoplastic T cells may be a minor cell population. A molecular single-cell and immunohistochemical study
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Journal Article
In angioimmunoblastic T-cell lymphoma, neoplastic T cells may be a minor cell population. A molecular single-cell and immunohistochemical study
2005
Overview
The significance of T-cell proliferations in angioimmunoblastic lymphoma (AILD) is still enigmatic. Although classified as a malignant T-cell lymphoma in the World Health Organisation lymphoma classification, some cases of AILD lack dominant T-cell clones. In a previous study, based on single-cell polymerase chain reaction (PCR), we obtained similar results as studies of AILD using Southern blot or conventional PCR: some cases of AILD contained large T-cell clones, and, in other cases, T-cell clones were undetectable. As in single-cell studies, only a limited number of cells could be investigated; thus, we wanted to gain more insight into the amount and distribution of tumour cells. By applying triple immunofluorescent staining with antibodies directed against T-cell receptor Vbeta-family-specific epitopes, we investigated T-cell populations in AILD and their localisation in the tissue in relation to B cells (CD20) and follicular dendritic cells (CD21). In two of five cases investigated, only a minority of the T-cells compartment belonged to the tumour clone. Neoplastic T cells were found throughout the tissue, including areas dominated by B cells.
Publisher
Springer,Springer Nature B.V
Subject
/ Biological and medical sciences
/ Cells
/ Fluorescent Antibody Technique
/ Humans
/ Immunoblastic Lymphadenopathy - immunology
/ Immunoblastic Lymphadenopathy - pathology
/ Investigative techniques, diagnostic techniques (general aspects)
/ Lymphoma
/ Lymphoma, T-Cell - immunology
/ Lymphoma, T-Cell - pathology
/ Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
/ Receptors, Antigen, T-Cell, alpha-beta - analysis
