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Modulation of T‐cell function by type I interferon
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Journal Article
Modulation of T‐cell function by type I interferon
2012
Overview
Production of type I interferon (IFN‐α/β) is a common cellular response to virus infection. IFN‐α/β has a dual role in combating infection, triggering innate antiviral mechanisms and stimulating the generation of an adaptive immune response. This review focuses on the effects of IFN‐α/β on one particular immune cell type, the T cell, and the impact of IFN‐α/β‐mediated signalling in T cells on the immune response. The critical role of T‐cell responsiveness to IFN‐α/β for the generation of productive T‐cell responses after infections with certain viruses in vivo is discussed in the context of in vitro experiments investigating the mechanisms by which IFN‐α/β modifies T‐cell function. These studies reveal complex effects of IFN‐α/β on T cells, with the consequences of exposure to IFN‐α/β depending on the context of other signals received by the T cell. The innate immune response recognises pathogens and sterile danger signals to generate effector cytokines, such as type I interferons (IFNs), with a high degree of sophistication. The May/June 2012 issue provides a series of reviews of the role of type I IFNs in regulating immune responses. Topics to be covered include the reason for the induction of IFNs, type I IFNs interactions with and regulation of target cells (e.g. T cells, B cells and Th10 cells) in the immune system, and the roles and mechanisms of IFNs in specific organs or diseases. The accompanying web focus presents links to related articles from across Nature Publishing Group to provide more background information about these proteins.
Publisher
Nature Publishing Group,Blackwell Science Ltd
