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Toward unbiased objective functions in constraint-based modeling
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Journal Article
Toward unbiased objective functions in constraint-based modeling
2026
Overview
The objective function is important to constraint-based modeling, but setting it has traditionally been subjective, limiting predictive accuracy. We expose the biases of commonly used objective functions and propose a paradigm shift toward unbiased objective functions powered by artificial intelligence, offering a promising avenue for metabolic engineering and biomedical applications.
The objective function is important to constraint-based modeling, but setting it has traditionally been subjective, limiting predictive accuracy. We expose the biases of commonly used objective functions and propose a paradigm shift toward unbiased objective functions powered by artificial intelligence, offering a promising avenue for metabolic engineering and biomedical applications.
Publisher
Elsevier Ltd
