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Myocardial Fibrosis as a Potential Maladaptive Feature of Right Ventricle Remodeling in Pulmonary Hypertension
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Myocardial Fibrosis as a Potential Maladaptive Feature of Right Ventricle Remodeling in Pulmonary Hypertension
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Journal Article
Myocardial Fibrosis as a Potential Maladaptive Feature of Right Ventricle Remodeling in Pulmonary Hypertension
2019
Overview
In this issue of the Journal, Jankowich and colleagues (pp. 776–779) use myocardial ECV assessment in patients with PH to investigate the relationship between diffuse interstitial fibrosis in the RV free wall and pulmonary artery (PA) stiffness, as measured by PA pulse wave velocity and PA relative area change (6). The authors found a strong positive correlation between RV ECV and PA pulse wave velocity (0.73; P = 0.001) and a strong negative correlation between RV ECV and PA relative area change (−0.69; P = 0.003), supporting a relationship between RV fibrosis and PA stiffness in this cohort. Given previously reported associations between measures of PA stiffness and poor clinical outcomes in PH, the authors suggest that RV fibrosis may be an early marker of deleterious RV remodeling, observed in this cohort before deterioration in any functional metric, such as RVEF.
Publisher
Oxford University Press,American Thoracic Society
