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The gut resistome is highly dynamic during the first months of life
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Journal Article
The gut resistome is highly dynamic during the first months of life
2016
Overview
We investigated the longitudinal development of several antibiotic resistance genes (ARGs) of the infant gut resistome during the first months after birth.
Fecal samples from 120 infants collected at the ages of 5, 13 and 31 weeks were analyzed and subjected to qPCR for the detection of several ARGs.
The prevalence of ARGs significantly increased for
and
, while it decreased for
. Birth mode and breastfeeding significantly affected
prevalence. Correlations to bacterial taxa suggest that fluctuations in some ARGs are (partly) attributed to shifts in bacteroides colonization rates.
Acquisition of ARGs in the gut microbiota occurs shortly after birth and resistome composition fluctuates over the course of several months, reflecting changes in microbial community structure.
Publisher
Future Medicine Ltd
Subject
