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A Randomized Clinical Trial of Propranolol for the Prevention of Initial Bleeding in Cirrhosis with Portal Hypertension
by
Tinè, F
, Filippazzo, M G
, D'Amico, G
, Morabito, A
, Ferrari, A
, Marenco, G
, Pagliaro, L
, De Pretis, G
, Pasta, L
in
Clinical Trials as Topic
/ Gastrointestinal Hemorrhage - prevention & control
/ Humans
/ Hypertension, Portal - complications
/ Hypertension, Portal - drug therapy
/ Liver Cirrhosis - complications
/ Liver Cirrhosis - drug therapy
/ Propranolol - therapeutic use
/ Random Allocation
1986
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A Randomized Clinical Trial of Propranolol for the Prevention of Initial Bleeding in Cirrhosis with Portal Hypertension
by
Tinè, F
, Filippazzo, M G
, D'Amico, G
, Morabito, A
, Ferrari, A
, Marenco, G
, Pagliaro, L
, De Pretis, G
, Pasta, L
in
Clinical Trials as Topic
/ Gastrointestinal Hemorrhage - prevention & control
/ Humans
/ Hypertension, Portal - complications
/ Hypertension, Portal - drug therapy
/ Liver Cirrhosis - complications
/ Liver Cirrhosis - drug therapy
/ Propranolol - therapeutic use
/ Random Allocation
1986
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A Randomized Clinical Trial of Propranolol for the Prevention of Initial Bleeding in Cirrhosis with Portal Hypertension
by
Tinè, F
, Filippazzo, M G
, D'Amico, G
, Morabito, A
, Ferrari, A
, Marenco, G
, Pagliaro, L
, De Pretis, G
, Pasta, L
in
Clinical Trials as Topic
/ Gastrointestinal Hemorrhage - prevention & control
/ Humans
/ Hypertension, Portal - complications
/ Hypertension, Portal - drug therapy
/ Liver Cirrhosis - complications
/ Liver Cirrhosis - drug therapy
/ Propranolol - therapeutic use
/ Random Allocation
1986
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A Randomized Clinical Trial of Propranolol for the Prevention of Initial Bleeding in Cirrhosis with Portal Hypertension
Journal Article
A Randomized Clinical Trial of Propranolol for the Prevention of Initial Bleeding in Cirrhosis with Portal Hypertension
1986
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Overview
To the Editor:
Propranolol reduces portal hypertension in cirrhosis
1
and has been evaluated for the prevention of rebleeding.
2
,
3
We report here preliminary results of a multicenter randomized clinical trial in patients with cirrhosis who had never bled but were at high risk of bleeding (patients with large varices on endoscopy: \"F3,\" according to the criteria of the Japanese Research Society for Portal Hypertension
4
). Subjects with tense ascites, a bilirubin level over 3 mg per deciliter, heart failure, obstructive lung disease, or hepatocellular carcinoma were excluded. This allowed the admission of 174 patients of 220 consecutively observed at four centers . . .
Publisher
Massachusetts Medical Society
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