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In vitro Dosimetric Study of Biliary Stent Loaded with Radioactive ^125I Seeds
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In vitro Dosimetric Study of Biliary Stent Loaded with Radioactive ^125I Seeds
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Journal Article
In vitro Dosimetric Study of Biliary Stent Loaded with Radioactive ^125I Seeds
2017
Overview
Background： A novel radioactive ^125I seed-loaded biliary stent has been used for patients with malignant biliary obstruction. However, the dosimetric characteristics of the stents remain unclear. Therefore, we aimed to describe the dosimetry of the stents of different lengths -- with different number as well as activities of ^125I seeds. Methods： The radiation dosimetry of three representative radioactive stent models was evaluated using a treatment planning system （TPS）, thermoluminescent dosimeter （TLD） measurements, and Monte Carlo （MC） simulations. In the process of TPS calculation and TLD measurement, two different water-equivalent phantoms were designed to obtain cumulative radial dose distribution. Calibration procedures using TLD in the designed phantom were also conducted. MC simulations were performed using the Monte Carlo N-Particle extended version 2.5 general purpose code to calculate the radioactive stent＇s three-dimensional dose rate distribution in liquid water. Analysis of covariance was used to examine the factors influencing radial dose distribution of the radioactive stent. Results： The maximum reduction in cumulative radial dose was 26% when the seed activity changed from 0.5 mCi to 0,4 mCi for the same length of radioactive stents. The TLD＇s dose response in the range of 0-10 mGy irradiation by ^137Cs y-ray was linear： y = 182225x - 6651.9 （R2 = 0.99152; y is the irradiation dose in mGy, x is the TLDs＇ reading in nC）. When TLDs were irradiated by different energy radiation sources to a dose of 1 mGy, reading of TLDs was different. Doses at a distance of 0.1 cm from the three stents＇ surface simulated by MC were 79, 93, and 97 Gy. Conclusions： TPS calculation, TLD measurement, and MC simulation were performed and were found to be in good agreement. Although the whole experiment was conducted in water-equivalent phantom, data in our evaluation may provide a theoretical basis for dosimetry for the clinical application.
Publisher
Lippincott Williams & Wilkins Ovid Technologies,Department of Radiation Oncology, Lynn Cancer Institute, Boca Raton, FL 33486, USA%Department of Computer Science and Engineering, University of Washington, Seattle, WA 98195, USA%LMAM, School of Mathematical Sciences, Peking University, Beijing 100871, China,Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China%Department of Physics, Florida Atlantic University, Boca Raton, FL 33431, USA,Medknow Publications & Media Pvt Ltd,Wolters Kluwer
