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Fused Thiopyrano2,3-dthiazole Derivatives as Potential Anticancer Agents
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Fused Thiopyrano2,3-dthiazole Derivatives as Potential Anticancer Agents
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Journal Article
Fused Thiopyrano2,3-dthiazole Derivatives as Potential Anticancer Agents
2012
Overview
rel-(5aR,11bR)-3,5a,6,11b-tetrahydro-2H,5H-chromeno[4',3':4,5]thiopyrano[2,3-d][1,3]thiazol-2-ones formed by the stereoselective Knoevenagel-hetero-Diels-Alder reaction were functionalized at the nitrogen in position 3 via reactions of alkylation, cyanoethylation, and acylation. The synthesized compounds were evaluated for their anticancer activity in NCI60 cell lines. Among the tested compounds, 3f was found to be the most active candidate with the greatest influence on leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, prostate cancer, and breast cancer subpanel cell lines with GI(50) values over a range of 0.37-0.67 μM.
Publisher
MDPI AG,Österreichische Apotheker-Verlagsgesellschaft
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