Journal Article

Endometrial preparation with Dienogest before hysteroscopic surgery: a systematic review

Agnese Maria Chiara Rapisarda, Palmara, Vittorio, Rossetti, Paola, Helena Ban Frangež, Triolo, Onofrio, Vitale, Salvatore Giovanni, Laganà, Antonio Simone, Muscia, Vincenzo, Buscema, Massimo, Granese, Roberta, Romano, Andrea, Giunta, Loretta

2017

Overview

PurposeHysteroscopic surgery is considered the gold standard for the minimal invasive treatment of many endouterine diseases such as endometrial polyps or submucous myomas. Recently, many studies have evaluated the effect of preoperative administration of a number of drugs to reduce endometrial thickness and achieve important intraoperative advantages. The purpose of this systematic review is to summarize the available evidence about the use of Dienogest, an orally administrable progestin, for endometrial preparation before hysteroscopic surgery.MethodsAll studies published on this topic and indexed on PubMed/MEDLINE, Embase or Google scholar databases were retrieved and analysed.ResultsWe retrieved five studies about this topic. Considered together, the published data analyses allow us to conclude that Dienogest is effective in reducing the thickness of the endometrium, the severity of bleeding and also of operative time, with a lower number of side effects compared with other pharmacological preparations or no treatment.ConclusionAdministration of Dienogest may be an effective and safe treatment for endometrial thinning before operative hysteroscopy. However, this conclusion is based on few reports and further studies to prove or disprove it are warranted.

• Publisher: Springer Nature B.V
• Subject: Hormone replacement therapy / Surgery / Systematic review