Journal Article

Do normative data specific to Greek Australian older adults improve validity of neuropsychological assessment results?

Papadopoulos, Alexandra, March, Evrim, Stolwyk, Renerus J., Kosmidis, Mary H., Nielsen, T. Rune, Kokkinias, Arthur, Staios, Mathew, Tsiaras, Yiannis, Velakoulis, Dennis

2023

Overview

This study aimed to compare Greek Australian and English language normative data with regard to impairment rates yielded within a healthy Greek Australian older adult sample. We also examined whether optimal cut scores could be identified and capable of sensitively and specifically distinguishing between healthy Greek Australians from those with a diagnosis of Alzheimer's disease (AD). Ninety healthy Greek Australian older adults and 20 demographically matched individuals with a diagnosis of AD completed a range of neuropsychological measures, including the Wechsler Adult Intelligence Scale-Fourth Edition, Greek Adaptation (WAIS-IV GR), verbal and visual memory, language and naming, and executive functions. Impairment rates derived from the use of either Greek Australian or English language normative data were calculated and compared, using a 1.5 standard deviation criterion to denote impairment. Receiver operating characteristics curve analysis was used to investigate the sensitivity and specificity of alternate cut scores. Impairment rates derived from the Greek Australian normative data showed that rates of impairment generally fell within the expected 7% range. In contrast, impairment rates for all tests derived using English language normative data were significantly higher and ranged from 11%-66%. Comparisons between healthy and AD participants with moderate dementia showed significant differences across all measures. Area under the curve results ranged from .721 to .999 across all measures, with most tests displaying excellent sensitivity and specificity. English language normative data were found to be inappropriate for use with Greek Australian elders, potentially leading to erroneous diagnostic outcomes. The use of minority group specific normative data and associated cut points appear to partially ameliorate this issue. Clinical implications are discussed alongside future research directions.

• Publisher: Cambridge University Press
• Subject: Adaptation / Adults / Aged / Alzheimer Disease - diagnosis / Alzheimer Disease - psychology / Alzheimer's disease / Australia / Dementia / Dementia disorders / Diagnosis / Education / English language / Geriatrics / Greece / Humans / Intelligence / Language / Medical imaging / Memory / Minority & ethnic groups / Neurodegenerative diseases / Neuroimaging / Neuropsychological Tests / Neuropsychology / Older people / Tomography