Journal Article

Antiretroviral treatment indications and adherence to the German-Austrian treatment initiation guidelines in the German ClinSurv HIV Cohort between 1999 and 2016

Gunsenheimer-Bartmeyer, Barbara, Lehmann, Clara, Schmidt, Daniel, Jörg Janne Vehreschild, Platten, Martin, Kollan, Christian, Fätkenheuer, Gerd, Stecher, Melanie, Schommers, Philipp

2019

Overview

PurposeThe aim of the study was to assess guideline adherence to combined antiretroviral therapy (ART) in the German ClinSurv HIV Cohort and the real-life impact of the Strategic Timing of Antiretroviral Therapy (START) study, to identify patients not treated as recommended by new guidelines.MethodsWe used data from the multicenter ClinSurv cohort of the Robert-Koch-Institute (RKI) between 1999 and 2016. Inclusion criteria were people living with HIV/AIDS, ≥ 18 years of age and cART naïve at the first visit (FV). Adherence was defined as starting cART within 6 months of crossing the CD4+ T cell threshold as suggested by the German-Austrian treatment guidelines. Logistic regression was used to identify factors associated with non-adherence.Results11,817 patients met the inclusion criteria. We observed an overall adherence rate of 60%, in patients with treatment indication who started cART timely between 2002 and 2015. Adherence rate increased constantly, demonstrating a potential increase in patients, with treatment indication, starting cART within 6 months of presentation from 55% in 2008 to 94% in 2015. Patients reporting injection drug use (OR 2.18, 95% CI 1.70–2.95) and patients between 18 years and 39 years of age at the time of their first visit (OR 2.89, 95% CI 1.35–6.18) were identified as risk groups associated with non-adherence.ConclusionThe majority of patients below the CD4+ T cell count threshold of applicable guidelines initiated treatment within 6 months. We observed a slowly diminishing proportion of patients not starting cART timely. Delayed treatment was more frequent in patients reporting injection drug use.

• Publisher: Springer Nature B.V
• Subject: Acquired immune deficiency syndrome / Adhesion / AIDS / Antiretroviral agents / Antiretroviral drugs / Antiretroviral therapy / CD4 antigen / Drug therapy / Drug use / Guidelines / HIV / Human immunodeficiency virus / Identification methods / Indication / Injection / Lymphocytes / Lymphocytes T / Patient compliance / Patients / Risk groups / Substance abuse treatment / Therapy