Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Epigenomic analysis of Parkinson’s disease neurons identifies Tet2 loss as neuroprotective

by Cui, Wei , Killinger, Bryan A , Weiland, Matthew , Marshall, Lee L , Wang, Xinhe , Ma, Jiyan , Labrie, Viviane , Ensink, Elizabeth , Coetzee, Gerhard A , Jovinge, Stefan , Li, Peipei , Lubben, Noah , Li, Katie X , Gordevicius, Juozas

in Cytosine / Deactivation / DNA methylation / Dopamine receptors / Enhancers / Epigenetics / Genomes / Immune response / Inactivation / Inflammation / Movement disorders / Neurodegenerative diseases / Neurons / Neuroprotection / Parkinson's disease / Pathogenesis / Substantia nigra / Therapeutic targets / Up-regulation

2020

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Epigenomic analysis of Parkinson’s disease neurons identifies Tet2 loss as neuroprotective

2020

Confirm

Do you wish to request the book?

Epigenomic analysis of Parkinson’s disease neurons identifies Tet2 loss as neuroprotective

2020

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Epigenomic analysis of Parkinson’s disease neurons identifies Tet2 loss as neuroprotective

Cui, Wei,

Killinger, Bryan A,

Weiland, Matthew,

Marshall, Lee L,

Wang, Xinhe,

Ma, Jiyan,

Labrie, Viviane,

Ensink, Elizabeth,

Coetzee, Gerhard A,

Jovinge, Stefan,

Li, Peipei,

Lubben, Noah,

Li, Katie X,

Gordevicius, Juozas

2020

Overview

Parkinson’s disease (PD) pathogenesis may involve the epigenetic control of enhancers that modify neuronal functions. Here, we comprehensively examine DNA methylation at enhancers, genome-wide, in neurons of patients with PD and of control individuals. We find a widespread increase in cytosine modifications at enhancers in PD neurons, which is partly explained by elevated hydroxymethylation levels. In particular, patients with PD exhibit an epigenetic and transcriptional upregulation of TET2, a master-regulator of cytosine modification status. TET2 depletion in a neuronal cell model results in cytosine modification changes that are reciprocal to those observed in PD neurons. Moreover, Tet2 inactivation in mice fully prevents nigral dopaminergic neuronal loss induced by previous inflammation. Tet2 loss also attenuates transcriptional immune responses to an inflammatory trigger. Thus, widespread epigenetic dysregulation of enhancers in PD neurons may, in part, be mediated by increased TET2 expression. Decreased Tet2 activity is neuroprotective, in vivo, and may be a new therapeutic target for PD.Parkinson’s disease brain neurons exhibit a widespread epigenetic dysregulation of enhancers that is linked to an upregulation of TET2. Inactivation of TET2 protects against nigral dopaminergic neuronal loss and neuroinflammation.

Share this book

Add to My Shelf

Publisher

Nature Publishing Group

Subject

/ Genomes