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Effect of On-Demand Oral Pre-exposure Prophylaxis With Tenofovir/Emtricitabine on Herpes Simplex Virus-1/2 Incidence Among Men Who Have Sex With Men: A Substudy of the ANRS IPERGAY Trial

by Breaud, S , Hue, H , Adouard-groslafeige, C , Godinot, M , Cheret, A , Beauvais, C , Hall, N , Sagaon-Teyssier, L , Pasquet, Armelle , Mahjoub, N , Cua, E , Leturque, N , Diallo, Alpha , Robineau, O , Talbot, A , Gilly, L , Cavellec, M , Rozenbaum, W , Tremblay, C , Monfort, C , Colas, M , Raffi, F , Delaugerre, C , Mennecier, A , Etien, N , Suzan, M , Loze, B , Clement, F , Cattin, G , Roger, PM , Bajos, Nathalie , Veron, R , Saouzanet, M , Madelaine, I , Fortin, C , Morin, M , Koffi, J , Chas, J , Lorho, F , Bagge, S , Charreau, Isabelle , Chapolard, C , Aboulker, Jean-Pierre , Charreau, I , Vandamme, S , Pialoux, G , Besnier, Michel , Porion, R , Castro, Daniela Rojas , Dalle, E , Choquet, R , Thompson, David , Boissavy, B , Larmet, L , Binesse, J , Delgado, J , Molina, J M , Djessima, A , Lert, France , Cousseau, S , Wainberg, M , Meyer, Laurence , Berdougo, J , Molina, Jean-Michel , Girard, Gabriel , Gibowski, Séverine , Moudachirou, K , Delfraissy, J-F , Cotte, Laurent , Nagat, S le , Diallo, A , Durand-Zaleski, Isabelle , Marchand, L , Spire, B , Chamberland, A , Raffi, François , Teruin, X , Bernaud, C , Carette, D , Brunet, P , Tolonin, F , Huleux, T , Simon, M-C , Fonsart, Julien , Mahjoub, Nadia , Blanchette, M , Chidiac, C , Etie

in Brief Report / Life Sciences

2018

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Effect of On-Demand Oral Pre-exposure Prophylaxis With Tenofovir/Emtricitabine on Herpes Simplex Virus-1/2 Incidence Among Men Who Have Sex With Men: A Substudy of the ANRS IPERGAY Trial

in Brief Report / Life Sciences

2018

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Effect of On-Demand Oral Pre-exposure Prophylaxis With Tenofovir/Emtricitabine on Herpes Simplex Virus-1/2 Incidence Among Men Who Have Sex With Men: A Substudy of the ANRS IPERGAY Trial

in Brief Report / Life Sciences

2018

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Journal Article

Effect of On-Demand Oral Pre-exposure Prophylaxis With Tenofovir/Emtricitabine on Herpes Simplex Virus-1/2 Incidence Among Men Who Have Sex With Men: A Substudy of the ANRS IPERGAY Trial

Breaud, S,

Hue, H,

Adouard-groslafeige, C,

Godinot, M,

Cheret, A,

Beauvais, C,

Hall, N,

Sagaon-Teyssier, L,

Pasquet, Armelle,

Mahjoub, N,

Cua, E,

Leturque, N,

Diallo, Alpha,

Robineau, O,

Talbot, A,

Gilly, L,

Cavellec, M,

Rozenbaum, W,

Tremblay, C,

Monfort, C,

Colas, M,

Raffi, F,

Delaugerre, C,

Mennecier, A,

Etien, N,

Suzan, M,

Loze, B,

Clement, F,

Cattin, G,

Roger, PM,

Bajos, Nathalie,

Veron, R,

Saouzanet, M,

Madelaine, I,

Fortin, C,

Morin, M,

Koffi, J,

Chas, J,

Lorho, F,

Bagge, S,

Charreau, Isabelle,

Chapolard, C,

Aboulker, Jean-Pierre,

Charreau, I,

Vandamme, S,

Pialoux, G,

Besnier, Michel,

Porion, R,

Castro, Daniela Rojas,

Dalle, E,

Choquet, R,

Thompson, David,

Boissavy, B,

Larmet, L,

Binesse, J,

Delgado, J,

Molina, J M,

Djessima, A,

Lert, France,

Cousseau, S,

Wainberg, M,

Meyer, Laurence,

Berdougo, J,

Molina, Jean-Michel,

Girard, Gabriel,

Gibowski, Séverine,

Moudachirou, K,

Delfraissy, J-F,

Cotte, Laurent,

Nagat, S le,

Diallo, A,

Durand-Zaleski, Isabelle,

Marchand, L,

Spire, B,

Chamberland, A,

Raffi, François,

Teruin, X,

Bernaud, C,

Carette, D,

Brunet, P,

Tolonin, F,

Huleux, T,

Simon, M-C,

Fonsart, Julien,

Mahjoub, Nadia,

Blanchette, M,

Chidiac, C,

Etie

2018

Overview

We evaluated the impact of on-demand oral tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC) for pre-exposure prophylaxis (PrEP) on herpes simplex virus (HSV)-1/2 incidence among men who have sex with men (MSM) enrolled in the ANRS IPERGAY trial. Serum samples were tested at baseline and at the last visit for HSV-1/2 antibodies. Overall HSV-1 incidence was 11.7 per 100 person-years; 16.2 and 7.8 per 100 person-years in the TDF/FTC and placebo arm, respectively (P = .19). Overall HSV-2 incidence was 7.6 per 100 person-years; 8.1 and 7.0 per 100 person-years in the TDF/FTC and placebo arm, respectively (P = .75). On-demand oral PrEP with TDF/FTC failed to reduce HSV-1/2 incidence in this population.

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Publisher

Oxford University Press

Subject

Brief Report

/ Life Sciences