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Perineural spread to the brachial plexus: a focused review of proposed mechanisms and described pathologies
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Perineural spread to the brachial plexus: a focused review of proposed mechanisms and described pathologies
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Journal Article
Perineural spread to the brachial plexus: a focused review of proposed mechanisms and described pathologies
2020
Overview
BackgroundPerineural spread (PNS) is an emerging mechanism for progressive, non-traumatic brachial plexopathy. We aim to summarize the pathologies (tumor and infection) shown to have spread along or to the brachial plexus, and identify the proposed mechanisms of perineural spread.MethodsA focused review of the literature was performed pertaining to pathologies with identified perineural spread to the brachial plexus.ResultsWe summarized pathologies currently reported to have PNS in the brachial plexus and offer a structure for understanding and describing these pathologies with respect to their interaction with the peripheral nervous system.ConclusionsPerineural spread is an underrepresented entity in the literature, especially regarding the brachial plexus. It can occur via a primary or secondary mechanism based on the anatomy, and understanding this mechanism helps to support biopsies of sacrificial nerve contributions, leading to more effective and timely treatment plans for patients.
Publisher
Springer Nature B.V
Subject
