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Health-related quality of life overview after different curative treatment options in muscle-invasive bladder cancer: an umbrella review
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Health-related quality of life overview after different curative treatment options in muscle-invasive bladder cancer: an umbrella review
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Journal Article
Health-related quality of life overview after different curative treatment options in muscle-invasive bladder cancer: an umbrella review
2020
Overview
Purpose
This umbrella review aims to evaluate the quality, summarize and compare the conclusions of systematic reviews investigating the impact of curative treatment options on health-related quality of life (HRQoL) in muscle-invasive bladder cancer (MIBC).
Methods
The Cochrane Library, MEDLINE, Embase and Web of Science were searched independently by two authors from inception until 06 January 2020. Systematic reviews and meta-analyses assessing the impact of any curative treatment option on HRQol in MIBC patients were eligible. Risk of bias was assessed using the AMSTAR 2 tool.
Results
Thirty-two reviews were included. Robot-assisted RC with extracorporeal urinary diversion and open RC have similar HRQoL (
n
= 10). Evidence for pelvic organ-sparing RC was too limited (
n
= 2). Patients with a neobladder showed better overall and physical HRQoL outcomes, but worse urinary function in comparison with ileal conduit (
n
= 17). Bladder-preserving radiochemotherapy showed slightly better urinary and sexual but worse gastro-intestinal HRQoL outcomes in comparison with RC patients (
n
= 6). Quality of the reviews was low in more than 50% of the available reviews and most of the studies included in the reviews were nonrandomized studies.
Conclusion
This umbrella review gives a comprehensive overview of the available evidence to date.
Publisher
Springer International Publishing,Springer Nature B.V
