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Lipidic extract of whole tomato reduces hyperplasia, oxidative stress and inflammation on testosterone-induced BPH in obese rats
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Lipidic extract of whole tomato reduces hyperplasia, oxidative stress and inflammation on testosterone-induced BPH in obese rats
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Journal Article
Lipidic extract of whole tomato reduces hyperplasia, oxidative stress and inflammation on testosterone-induced BPH in obese rats
2023
Overview
Purpose
Tomato is an important source of lycopene, a carotenoid that has been emerging as a natural preventive agent for prostate disease. Moreover, tomato contains other components with a wide range of physiological properties, but their potential beneficial effects on prostatic hyperplasia (PH) during obesity have not been completely established. In this study, we compared the effect of a lipidic extract of tomato saladette (STE) with
Serenoa repens
(
SR
) on obese rats with PH.
Methods
Forty-eight Wistar rats were divided in Control (C) and Obese (Ob) treated without (
n
= 12) and with (
n
= 36) testosterone enanthate (TE), once a week for 8 weeks to induce PH. After 4 weeks,
SR
and STE were administered. Biochemical parameters, oxidative stress markers and inflammatory cytokines production were determined.
Results
TE increased prostate weight and caused prostatic hyperplasia in C group, and these effects were exacerbated by obesity.
SR
and STE reverted the increase in prostate weight and hyperplasia caused by TE in C and Ob groups. Obesity increased LDL, TGs, NOx and MAD, but decreased HDLc, GSx, SOD and CAT.
SR
reverted the effects of obesity, but these were significantly reduced and HDLc increased with STE. Obesity and TE increased TNFα, IL-1β and IL-6 levels, but these were partially reverted by STE compared with
SR
.
Conclusions
Excess of fat tissue increases the alterations by PH. STE diminishes these alterations compared with
SR
, suggesting its beneficial effect to improve prostate function. Whole tomato lipid extract could serve as sole therapy or as an adjunct to pharmacological treatment for PH.
Publisher
Springer Netherlands,Springer Nature B.V
Subject
