Journal Article

Membrane-stabilizing and protective effects of curcumin in a rotenone-induced rat model of Parkinson disease

Simonyan, K. V., Manukyan, L. P., Darbinyan, L. V., Simonyan, M. A., Simonyan, R. M., Hambardzumyan, L. E.

2023

Overview

Parkinson disease (PD) is a chronic progressive neurodegenerative disease characterized by both motor and non-motor features. Numerous risk factors (oxidative stress, free radical formation, and several environmental toxins) have been associated with PD. The experimental studies were carried out under in vivo conditions. Biochemical data analysis indicated that compared with the parameters of control (C) rats, rotenone-induced PD rats showed a significant decrease in the specific content of the total fraction of isoforms of O 2 − -producing, heat-stable, NADPH-containing associates (NLP-Nox) from membrane formations of tissues (brain, liver, lung, and small intestine). Compared with the C group indices, in the PD and PD + curcumin (PD + CU) groups there is some change in the shape of the optical absorption spectra of isoforms associated with a change in the amount of Nox in the isoform composition of the total fraction of the NLP-Nox associate. Thus, daily administration of CU (200 mg/kg, i.p.) to PD rats for 63 days had a regulatory effect, bringing the specific content and O 2 − -producing activity of the total fraction of NLP-Nox isoforms closer to the norm. CU has membrane-stabilizing effects in rotenone-induced PD.

• Publisher: Springer US,Springer Nature B.V
• Subject: Absorption spectra / Biochemistry / Biomedical and Life Sciences / Biomedicine / Curcumin / Data analysis / Free radicals / In vivo methods and tests / Intestine / Isoforms / Membranes / Metabolic Diseases / Movement disorders / Neurodegenerative diseases / Neurology / Neurosciences / Oncology / Original Article / Oxidative stress / Parkinson's disease / Risk factors / Rotenone / Small intestine / Thermal stability / Toxins