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Prevalence and risk factors of silent brain infarcts in patients with AF detected by 3T-MRI
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Prevalence and risk factors of silent brain infarcts in patients with AF detected by 3T-MRI
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Prevalence and risk factors of silent brain infarcts in patients with AF detected by 3T-MRI
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Journal Article
Prevalence and risk factors of silent brain infarcts in patients with AF detected by 3T-MRI
2020
Overview
Background
Silent brain infarcts (SBI), a finding on neuroimaging, are associated with higher risk of future stroke. Atrial Fibrillation (AF) has been previously identified as a cause of SBI.
Objectives
The aim of this study is to determine the prevalence of and risk factors for SBI in patients with AF and low-to-moderate embolic risk according to CHADS
2
and CHA
2
DS
2
VASc score.
Methods
Patients with a history of AF based on medical records who scored 0–1 in the CHADS
2
score were selected from the Seville urban area using the Andalusian electronic healthcare database (DIRAYA). Demographic and clinical data were collected and a 3T brain MRI was performed on patients older than 50 years and with absence of neurological symptoms.
Results
66 of the initial 443 patients (14.9%) and 41 of the 349 patients with low risk according to CHA
2
DS
2
VASc score (11.7%) presented at least 1 SBI. After adjusted multivariable analysis, an older age (OR 3.84, 95% CI 1.07–13.76) and left atrial (LA) enlargement (OR 3.13, 95% CI 1.15–8.55) were associated with SBI in the whole cohort, while only LA enlargement was associated with SBI in the low-risk cohort (OR 3.19, 95% CI 1.33–7.63).
Conclusions
LA enlargement on echocardiogram was associated with SBI in patients with AF and low or moderate embolic risk according to CHADS
2
and in the low-risk population according to CHA
2
DS
2
VASc. Although further studies are needed, a neuroimaging screening might be justified in these patients to guide medical therapies to improve stroke prevention.
Publisher
Springer Berlin Heidelberg,Springer Nature B.V
