Journal Article

Using radiomics-based modelling to predict individual progression from mild cognitive impairment to Alzheimer’s disease

Jiang, Jiehui, Li, Taoran, Han, Ying, Initiative, for the Alzheimer’s Disease Neuroimaging, Rominger, Axel, Alberts, Ian, Shi, Kuangyu, Wang, Min, Sun, Xiaoming, Zuo, Chuantao

2022

Overview

Background Predicting the risk of disease progression from mild cognitive impairment (MCI) to Alzheimer’s disease (AD) has important clinical significance. This study aimed to provide a personalized MCI-to-AD conversion prediction via radiomics-based predictive modelling (RPM) with multicenter 18F-fluorodeoxyglucose positron emission tomography (FDG PET) data. Method FDG PET and neuropsychological data of 884 subjects were collected from Huashan Hospital, Xuanwu Hospital, and from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database. First, 34,400 radiomic features were extracted from the 80 regions of interest (ROIs) for all PET images. These features were then concatenated for feature selection, and an RPM model was constructed and validated on the ADNI dataset. In addition, we used clinical data and the routine semiquantification index (standard uptake value ratio, SUVR) to establish clinical and SUVR Cox models for further comparison. FDG images from local hospitals were used to explore RPM performance in a separate cohort of individuals with healthy controls and different cognitive levels (a complete AD continuum). Finally, correlation analysis was conducted between the radiomic biomarkers and neuropsychological assessments. Results The experimental results showed that the predictive performance of the RPM Cox model was better than that of other Cox models. In the validation dataset, Harrell’s consistency coefficient of the RPM model was 0.703 ± 0.002, while those of the clinical and SUVR models were 0.632 ± 0.006 and 0.683 ± 0.009, respectively. Moreover, most crucial imaging biomarkers were significantly different at different cognitive stages and significantly correlated with cognitive disease severity. Conclusion The preliminary results demonstrated that the developed RPM approach has the potential to monitor progression in high-risk populations with AD.

• Publisher: Springer Berlin Heidelberg,Springer Nature B.V
• Subject: Advanced Image Analyses (Radiomics and Artificial Intelligence) / Alzheimer Disease - diagnostic imaging / Alzheimer's disease / Biomarkers / Cardiology / Cognitive ability / Cognitive Dysfunction - diagnostic imaging / Correlation analysis / Datasets / Disease Progression / Feature extraction / Fluorodeoxyglucose F18 / Humans / Imaging / Impairment / Medical imaging / Medicine / Medicine & Public Health / Mild cognitive impairment / Modelling / Neurodegenerative diseases / Neuroimaging / Neuropsychology / Nuclear Medicine / Oncology / Original Article / Orthopedics / Performance prediction / Positron emission / Positron emission tomography / Positron-Emission Tomography - methods / Prediction models / Radiology / Radiomics / Risk assessment / Tomography