Journal Article

Accumulative risk of clinical event in high-risk radiologically isolated syndrome in Argentina: data from the nationwide registry RelevarEM

Cristiano Edgardo, Luetic Geraldine, Tavolini Dario, Fiol Marcela, Cohen, Leila, Lopez, Pablo, Menichini, María L, Tkachuk Verónica, Silva, Berenice, Fernandez, Liguori Nora, Blaya Patricio, Alonso, Serena Marina, Liwacki Susana, Nofal, Pedro, Zanga Gisela, Knorre Eduardo, Alonso, Ricardo, Mainella Carolina, Garcea Orlando, Lequizamon Felisa, Carrá Adriana, Correale Jorge, Gaitán, María I, Barboza Andrés, Pappolla Agustín, Carnero Contentti Edgar, Burgos Marcos, Rojas, Juan I, Patrucco Liliana, Miguez Jimena, Ysrraelit, María C, Marrodán Mariano

2022

Overview

IntroductionWe aimed to analyze the accumulative risk of MRI and OB factors for evolution from RIS to MS in subjects included in the Argentinean MS registry (NCT03375177).MethodsRIS subjects were identified according to RIS diagnosis criteria. Subjects were longitudinally followed with clinical and MRI at intervals of 6 months. Time from RIS identification to the first clinical event was estimated using Kaplan–Meier. Multivariable Cox regression models were created to assess the independent predictive value of demographic characteristics, as well as clinical, OB and MRI data on time to the first clinical event. The single and increased risk factor of evolution of RIS was quantified.ResultsA total of 88 RIS subjects, mean follow-up time 42 ± 4 months were included. 39 (44.3%) and 23 (26.1%) had a new MRI lesion or a clinical event, respectively, during the follow-up. OB (HR 5.9, 95% CI 1.29–10.1, p = 0.004), infratentorial lesions (HR 3.7, 95% CI 1.09–7.5) and spinal cord lesions (HR 5.3, 95% CI 1.4–8.2, p = 0.01) at RIS identification were independent predictors associated with a subsequent clinical event. The accumulative risk showed that when two of the three factors (OB, infratentorial or spinal cord lesions) were present the HR was 10.4, 95% CI 4.4–22, p < 0.001, and when three factors were present, it was HR 15.6, 95% CI 5.7–28, p < 0.001 for a relapse.ConclusionThe presence of three factors significantly increased the risk of clinical event; high-risk subjects should probably be managed by a different approach than those used for individuals without high-risk factors.

• Publisher: Springer Nature B.V
• Subject: Lesions / Magnetic resonance imaging / Neurology / Regression analysis / Risk factors / Spinal cord