Journal Article

Correlation study between bone metabolic markers, bone mineral density, and sarcopenia

Li, Y. S., He, M., Yang, G., Li, H. Z., Jin, H. F., Rahmati, M., Xie, W. Q., Ji, B. Z., Chen, L. L., Yu, D. J.

2024

Overview

Objective To investigate the correlation between bone metabolism markers, bone mineral density (BMD), and sarcopenia. Methods A total of 331 consecutive patients aged ≥ 60 years who were hospitalized between November 2020 and December 2021 were enrolled. Participants were divided into sarcopenia and non-sarcopenia groups according to the Asian Working Group on Sarcopenia criteria (AWGS, 2019). The clinical data, bone metabolism markers (β-CTX, N-MID, and TP1NP), and BMD were compared between the two groups. Results Age, β-CTX, and N-MID of the sarcopenia group were higher than those of the non-sarcopenia group ( P  < 0.05), but the BMD T values were lower than those of the non-sarcopenia group ( P  < 0.05). Binary logistic regression analysis showed that increased femoral neck BMD (FNBMD) was a protective factor for sarcopenia, while increased β-CTX was a risk factor. Pearson/Spearman correlation analysis showed that the diagnostic indices of sarcopenia were positively correlated with FNBMD and negatively correlated with β-CTX and N-MID. Multiple linear regression analysis revealed that BMI and FNBMD significantly positively affected muscle strength and appendicular skeletal muscle mass (ASM). The FNBMD significantly positively affected physical performance, while β-CTX significantly negatively affected muscle strength, ASM, and physical performance. Conclusion Increased FNBMD may be a protective factor against sarcopenia, and increased β-CTX may be a risk factor. The FNBMD significantly positively affected the diagnostic indices of sarcopenia, while β-CTX significantly negatively affected them. BMD and bone metabolism marker levels may be considered in early screening for sarcopenia.

• Publisher: Springer International Publishing,Springer Nature B.V
• Subject: Bone density / Bone diseases / Bone mineral density / Bone turnover / Collagen / Correlation analysis / Endocrinology / Fractures / Immunoassay / Internal Medicine / Medicine / Medicine & Public Health / Metabolic Diseases / Metabolism / Muscle strength / Musculoskeletal system / Older people / Original Article / Osteoporosis / Patients / Regression analysis / Risk factors / Sarcopenia / Skeletal muscle / Standard deviation / Weightlessness / Working groups