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Editorial: Regulatory T Cell Heterogeneity: Canonical and Non-Canonical Functions
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Editorial: Regulatory T Cell Heterogeneity: Canonical and Non-Canonical Functions
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Journal Article
Editorial: Regulatory T Cell Heterogeneity: Canonical and Non-Canonical Functions
2021
Overview
[...]ablation of PPAR-γ or IL-33 specifically affects the VAT Treg cell population and compromises organismal glucose metabolism (5,7). Besides the transcription factors and cytokines, the structural component of the tissues such as mesenchymal stromal cells are known to imprint tissue specific features in Treg cells (8). The small intestine is predominantly populated by Gata3+ tTreg cells, which restrain inflammation and promote tissue repair to preserve gut homeostasis. Besides these populations, a specialized population of Bcl6+ Treg cells localized in the germinal centers (GCs) regulate the production of IgA and further contribute to gut health. Individual Intestinal Symbionts Induce a Distinct Population of RORgamma(+) Regulatory T Cells.Science(2015)349:993–7. doi:10.1126/science.aaa9420 5CipollettaDFeuererMLiAKameiNLeeJShoelsonSE.PPAR-Gamma Is a Major Driver of the Accumulation and Phenotype of Adipose Tissue Treg Cells.Nature(2012)486:549–53. doi:10.1038/nature11132 6NeumannCBlumeJRoyUTehPVasanthakumarABellerA.C-Maf-Dependent Treg Cell Control of Intestinal TH17 Cells and IgA Establishes Host-Microbiota Homeostasis.Nat Immunol(2019)20:471–81. doi:10.1038/s41590-019-0316-2 7VasanthakumarAMoroKXinALiaoYGlouryRKawamotoS.The Transcriptional Regulators IRF4, BATF and IL-33 Orchestrate Development and Maintenance of Adipose Tissue-Resident Regulatory T Cells.Nat Immunol(2015)16:276–85. doi:10.1038/ni.3085 8VasanthakumarAChisangaDBlumeJGlouryRBrittKHenstridgeD.Sex-Specific Adipose Tissue Imprinting of Regulatory T Cells.Nature(2020)579:581–5. doi:10.1038/s41586-020-2040-3 9HayatsuNMiyaoTTachibanaMMurakamiRKimuraAKatoT.Analyses of a Mutant Foxp3 Allele Reveal BATF as a Critical Transcription Factor in the Differentiation and Accumulation of Tissue Regulatory T Cells.Immunity(2017)47:268–83.e269. doi:10.1016/j.immuni.2017.07.008 10WingJBTanakaASakaguchiS.Human FOXP3(+) Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer.Immunity(2019)50:302–16. doi:10.1016/j.immuni.2019.01.020
Publisher
Frontiers Media SA,Frontiers Media S.A
Subject
/ Animals
/ Body fat
/ Cell Plasticity - immunology
/ Colon
/ Disease Susceptibility - immunology
/ Foxp3
/ Humans
/ Immunity
/ Interferon regulatory factor 4
/ Lymphocyte Activation - genetics
/ Lymphocyte Activation - immunology
/ Peroxisome proliferator-activated receptors
/ T-Lymphocyte Subsets - immunology
/ T-Lymphocyte Subsets - metabolism
/ T-Lymphocytes, Regulatory - immunology
